a comparison of clomiphene citrate and sequential clomiphene citrate plus human menopausal gonadotropin for use in conjunction with intrauterine insemination

there are currently ‎many different protocols in use for controlled ovarian hyperstimulation (coh), but the optimal method has ‎not yet been determined. to compare the outcome of coh using ‎clomiphene citrate (cc) versus cc plus human menopausal gonadotropin (hmg) in conjunction with intrauterine insemination (iui), we studied 117 infertile couples‎. iui with cc was used in 92 cycles ‎(group a) and iui with cc plus hmg was used in 66 cycles (group b). ‎data analysis demonstrated no significant difference between the two ‎groups with respect to patients’ age, duration and type of infertility, prior coh and endometrial thickness and pattern. group a had a little ‎longer follicular phase length than group b. ‎pregnancy rate for group a and b were 6.52% and 12.12%, respectively (p= 0.22). ‎endometrial pattern and thickness had no impact on pregnancy rate. ‎there were no multiple gestation and obvious hyperstimulation syndrome. ‎for patients undergoing controlled ovarian hyperstimulation with iui, ‎cc plus hmg protocol yields higher pregnancy rate than one using cc, although this ‎difference was not statistically significant because of limitation of number of ‎cycles.